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Chemical Structure : Metabolex-36
Catalog No.: PC-20424Not For Human Use, Lab Use Only.
Metabolex-36 is a potent, selective GPR120 (FFAR4) agonist with EC50 of 570 nM and 130 nM for stimulation of DMR response in CHO-hGPR120/mGPR120 cells, respectively.
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Metabolex-36 is a potent, selective GPR120 (FFAR4) agonist with EC50 of 570 nM and 130 nM for stimulation of DMR response in CHO-hGPR120/mGPR120 cells, respectively.
Metabolex-36 has IC50 of 1.3 uM calcium mobilization assays, does not activate mouse GPR40 in a calcium mobilization assay.
Metabolex-36 is selective for human and mouse GPR120 without activity on GPR40.
Metabolex-36 induces GPR120 dependent calcium mobilization, DMR response and cAMP production in GPR120 overexpressing cells.
Metabolex-36 (10 uM) inhibits cAMP production in mouse islets and increase GLP-1 secretion from STC-1 cells.
Metabolex-36 (30 mg/kg) improve oral glucose tolerance, increases insulin secretion in IVGTT in lean mice.
| M.Wt | 420.84 | |
| Formula | C21H19ClF2N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sundström L, et al. PLoS One. 2017 Dec 5;12(12):e0189060.
2. Ma J, et al. Aryl GPR120 receptor agonist and uses thereof. International patent WO 2020/048207. 2010.
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