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Chemical Structure : Microtubule inhibitor PP-13
Catalog No.: PC-72562Not For Human Use, Lab Use Only.
Microtubule inhibitor PP-13 is a novel microtubule-destabilizing agent, directly inhibits microtubule assembly by targeting the colchicine-binding site in β-tubulin.
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Microtubule inhibitor PP-13 is a novel microtubule-destabilizing agent, directly inhibits microtubule assembly by targeting the colchicine-binding site in β-tubulin.
PP-13 inhibits the growth of a wide range of cancer cell types, including targeted therapy-resistant and multidrug-resistant (MDR) cell lines (IC50=76-255 nM).
PP-13 overcomes the multidrug-resistant (MDR) phenotype in cancer cells, induces mitotic blockade in cancer cells, interferes with both mitotic microtubule organization and spindle pole integrity.
PP-13 induces cell prometaphase arrest then asymmetric division or direct apoptotic death.
PP-13 reduces tumour growth and metastasis invasion in vivo.
| M.Wt | 400.482 | |
| Formula | C24H24N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Pauline Gilson, et al. Sci Rep. 2017 Aug 31;7(1):10209.
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