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Midkine inhibitor (iMDK)

Chemical Structure : Midkine inhibitor (iMDK)

CAS No.: 881970-80-5

Midkine inhibitor (iMDK) (Inhibitor of Midkine)

Catalog No.: PC-61962Not For Human Use, Lab Use Only.

Midkine inhibitor (iMDK) is a small molecule inhibitor of the growth factor Midkine (MDK) that suppresses the endogenous expression of MDK but not other growth factors such as PTN or VEGF.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Midkine inhibitor (iMDK) is a small molecule inhibitor of the growth factor Midkine (MDK) that suppresses the endogenous expression of MDK but not other growth factors such as PTN or VEGF.
Midkine inhibitor (iMDK) inhibits the cell growth of MDK-positive H441 lung adenocarcinoma cells that harbor an oncogenic KRAS mutation and H520 squamous cell lung cancer cells, inhibits PI3K pathway and induces apoptosis.
Midkine inhibitor (iMDK) significantly inhibits tumor growth in a xenograft mouse model in vivo.

Physicochemical Properties

M.Wt 376.4
Formula C21H13FN2O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-[2-[(4-Fluorophenyl)methyl]imidazo[2,1-b]thiazol-6-yl]-2H-1-benzopyran-2-one

References

1. Hao H, et al. PLoS One. 2013 Aug 16;8(8):e71093.

2. Ishida N, et al. Exp Cell Res. 2015 Jul 15;335(2):197-206.

3. Masui M, et al. Anticancer Res. 2016 Jun;36(6):2775-81.

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