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Midodrine

Chemical Structure : Midodrine

CAS No.: 42794-76-3

Midodrine ((±)-Midodrine)

Catalog No.: PC-43176Not For Human Use, Lab Use Only.

Midodrine is a selective α1-adrenoceptor agonist that acts as a vasopressor/antihypotensive agent for the treatment of dysautonomia and orthostatic hypotension.

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Biological Activity

Midodrine is a selective α1-adrenoceptor agonist that acts as a vasopressor/antihypotensive agent for the treatment of dysautonomia and orthostatic hypotension.
Midodrine activates the alpha-adrenergic receptors of the arteriolar and venous vasculature, producing an increase in vascular tone and elevation of blood pressure.
Midodrine does not stimulate cardiac beta-adrenergic receptors, and diffuses poorly across the blood-brain barrier.

Physicochemical Properties

M.Wt 254.2823
Formula C12H18N2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Acetamide, 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]-

References

1. McTavish D, et al. Drugs. 1989 Nov;38(5):757-77.

2. Pittner H, et al. Arzneimittelforschung. 1976;26(12):2145-54.

3. Kontani H, et al. Jpn J Pharmacol. 1992 Apr;58(4):339-46.

4. Brune ME, et al. J Urol. 2001 Oct;166(4):1555-9.

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