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Milnacipran

Chemical Structure : Milnacipran

CAS No.: 92623-85-3

Milnacipran (F2207, Midalcipran)

Catalog No.: PC-28024Not For Human Use, Lab Use Only.

Milnacipran (F2207, Midalcipran) is is an antidepressant agent via selective inhibiting the uptake of monoamines, inhibits the uptake of radiolabelled serotonin and noradrenaline with IC50 of 203 and 100 nM, respectively, but not dopamine, shows no inhibition of the activity of monoamine oxidase in vitro or in vivo.

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Biological Activity

Milnacipran (F2207, Midalcipran) is is an antidepressant agent via selective inhibiting the uptake of monoamines, inhibits the uptake of radiolabelled serotonin and noradrenaline with IC50 of 203 and 100 nM, respectively, but not dopamine, shows no inhibition of the activity of monoamine oxidase in vitro or in vivo.

Physicochemical Properties

M.Wt 246.35
Formula C15H22N2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-diethyl-1-phenyl-, (1R,2S)-rel-

References

1. Assie MB, et al. Neuropharmacology. 1992 Feb;31(2):149-55.

2. Moret C, et al. Neuropharmacology. 1985 Dec;24(12):1211-9.

3. Ansseau M, et al. Eur Neuropsychopharmacol. 1991 May;1(2):113-21.

4. Shuto S, et al. J Med Chem. 1996 Nov 22;39(24):4844-52.

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