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Milveterol hydrochloride

Chemical Structure : Milveterol hydrochloride

CAS No.: 804518-03-4

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Milveterol hydrochloride (GSK 159797 hydrochloride )

Catalog No.: PC-62005Not For Human Use, Lab Use Only.

Milveterol (GSK 159797) is a potent, selective long-acting β2 adrenoceptor agonist with pEC50 of 10.2 in cell-based assays, displays good β2/β1 selectivity (>300-fold).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Milveterol (GSK 159797) is a potent, selective long-acting β2 adrenoceptor agonist with pEC50 of 10.2 in cell-based assays, displays good β2/β1 selectivity (>300-fold); demonstrates high potency in vitro and long duration of action in a guinea pig model of bronchoprotection.

Asthma

Phase 2 Discontinued

Physicochemical Properties

M.Wt 471.982
Formula C25H30ClN3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-hydroxy-5-((R)-1-hydroxy-2-((4-(((R)-2-hydroxy-2-phenylethyl)amino)phenethyl)amino)ethyl)phenyl)formamide hydrochloride

References

1. Jacobsen JR, et al. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1213-8.

2. Fuso L, et al. Curr Med Chem. 2013;20(12):1477-95.

3. Jacobsen JR, et al. Bioorg Med Chem Lett. 2014 Jun 15;24(12):2625-30.

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