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Chemical Structure : Milvexian
Catalog No.: PC-73462Not For Human Use, Lab Use Only.
Milvexian (BMS-986177, JNJ-70033093) is a highly potent, reversible, orally bioavailable factor XIa (FXIa) inhibitor with Ki of 0.11 and 0.38 nM for human and rabbit FXIa, respectively.
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Milvexian (BMS-986177, JNJ-70033093) is a highly potent, reversible, orally bioavailable factor XIa (FXIa) inhibitor with Ki of 0.11 and 0.38 nM for human and rabbit FXIa, respectively.
Milvexian (BMS-986177, JNJ-70033093) increased activated partial thromboplastin time (APTT) without changing prothrombin time and potently prolonged plasma APTT in humans and rabbits.
Milvexian (BMS-986177, JNJ-70033093) is an effective antithrombotic agent with limited impact on hemostasis, even when combined with aspirin in rabbits.
Milvexian (BMS-986177, JNJ-70033093) is a clinical candidate for the prevention and treatment of thromboembolic disorders.
| M.Wt | 626.450 | |
| Formula | C28H23Cl2F2N9O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Perera V, et al. Sci Rep. 2022 Mar 25;12(1):5165.
2. Weitz JI, et al. N Engl J Med. 2021 Dec 2;385(23):2161-2172.
3. Dilger AK, et al. J Med Chem. 2022 Feb 10;65(3):1770-1785.
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