Minesapride (DSP-6952)

Chemical Structure : Minesapride

Catalog No.: PC-60521Not For Human Use, Lab Use Only.

Minesapride (DSP-6952) is a novel potent, selective, orally active 5-HT4 receptor partial agonist with Ki of 50-100 nM for human 5-HT4a/4b/4c.

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Biological Activity

Minesapride (DSP-6952) is a novel potent, selective, orally active 5-HT4 receptor partial agonist with Ki of 50-100 nM for human 5-HT4a/4b/4c.
Minesapride (DSP-6952) enhances gastric motility and causes colonic giant migrating contractions (GMCs) associated with defecation in conscious dogs, having ED50 value for inducing GMCs of 1.56 mg/kg.
Minesapride (DSP-6952) rapidly increases fecal wet weight without increasing fluid content in mice (1-10 mg/kg, p.o.).

Physicochemical Properties

M.Wt	454.95
Formula	C21H31ClN4O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-amino-5-chloro-N-{[(2S)-4-{[1-(hydroxyacetyl)piperidin- 4-yl]methyl}morpholin-2-yl]methyl}-2-methoxybenzamide

References

1. Mine Y, et al. Eur J Pharmacol. 2018 Feb 9;826:123-132.

2. Tsubouchi T, et al. Eur J Pharmacol. 2018 Mar 1;826:96-105.