(Z)-Mirin is a small molecule inhibitor of MRN (Mre11-Rad50-Nbs1) pathway that inhibits Mre11-associated exonuclease activity.
(Z)-Mirin prevents MRN-dependent activation of ATM (IC50=12 uM) without affecting ATM protein kinase activity.
(Z)-Mirin inhibits Mre11 nuclease activity at 100 uM, does not inhibit ExoIII nuclease activity.
(Z)-Mirin inhibits the G2 checkpoint, and blocks homology-directed repair (HDR) in mammalian cells.
