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Chemical Structure : Mirin
CAS No.: 1198097-97-0
Catalog No.: PC-45763Not For Human Use, Lab Use Only.
(Z)-Mirin is a small molecule inhibitor of MRN (Mre11-Rad50-Nbs1) pathway that inhibits Mre11-associated exonuclease activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $138 | In stock | |
| 50 mg | $228 | In stock | |
| 100 mg | $398 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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(Z)-Mirin is a small molecule inhibitor of MRN (Mre11-Rad50-Nbs1) pathway that inhibits Mre11-associated exonuclease activity.
(Z)-Mirin prevents MRN-dependent activation of ATM (IC50=12 uM) without affecting ATM protein kinase activity.
(Z)-Mirin inhibits Mre11 nuclease activity at 100 uM, does not inhibit ExoIII nuclease activity.
(Z)-Mirin inhibits the G2 checkpoint, and blocks homology-directed repair (HDR) in mammalian cells.
| M.Wt | 220.2477 | |
| Formula | C10H8N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
4(5H)-Thiazolone, 2-amino-5-[(4-hydroxyphenyl)methylene]-, (5Z)- |
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1. Dupré A, et al. Nat Chem Biol. 2008 Feb;4(2):119-25.
2. Lee JH, et al. J Biol Chem. 2013 May 3;288(18):12840-51.
3. Rozier L, et al. Mol Cell. 2013 Mar 28;49(6):1097-107.
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