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Mitochonic acid 35

Chemical Structure : Mitochonic acid 35

CAS No.: 1611470-23-5

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Mitochonic acid 35 (MA-35, MA35)

Catalog No.: PC-60273Not For Human Use, Lab Use Only.

Mitochonic acid 35 (MA35) is a dual inhibitor of TNF-α and TGF-β1 by inhibiting IκB kinase phosphorylation and Smad3 phosphorylation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Mitochonic acid 35 (MA35) is a dual inhibitor of TNF-α and TGF-β1 by inhibiting IκB kinase phosphorylation and Smad3 phosphorylation.
    Mitochonic acid 35 attenuates the LPS/GaIN-induced hepatic inflammation in the mice, and downregulates TGF-β1-induced fibrotic gene expression.
    Mitochonic acid 35 attenuates renal inflammation and fibrosis with the downregulation of inflammatory cytokines and fibrotic gene expressions in renal fibrosis model.

    Physicochemical Properties

    M.Wt 341.36
    Formula C19H19NO5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-(3, 5-dimethoxybenzyloxy)-3-indoleacetic acid

    References

    1. Shima H, et al. Sci Rep. 2017 May 15;7(1):1884.

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