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Chemical Structure : Mizagliflozin
CAS No.: 666843-10-3
Catalog No.: PC-61451Not For Human Use, Lab Use Only.
Mizagliflozin (DSP-3235, KGA-3235, GSK-1614235) is a potent, selective, orally active SGLT1 inhibitor with Ki of 27 nM, displays >350-fold selectivity over SGLT2.
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|---|---|---|---|
| 2 mg | $128 | In stock | |
| 5 mg | $188 | In stock | |
| 10 mg | $318 | In stock | |
| 25 mg | $528 | In stock | |
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Mizagliflozin (DSP-3235, KGA-3235, GSK-1614235) is a potent, selective, orally active SGLT1 inhibitor with Ki of 27 nM, displays >350-fold selectivity over SGLT2.
Mizagliflozin increases stool frequency and loosens stool consistency in phase I study.
Mizagliflozin increases fecal wet weight in a dog model of loperamide-induced constipation and a rat model of low-fiber-diet-induced constipation, similar to lubiprostone.
| M.Wt | 564.68 | |
| Formula | C28H44N4O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-((3-(4-((5-isopropyl-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1H-pyrazol-4-yl)methyl)-3-methylphenoxy)propyl)amino)-2,2-dimethylpropanamide |
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1. Inoue T, et al. Eur J Pharmacol. 2017 Jul 5;806:25-31.
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