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Chemical Structure : Mocetinostat
CAS No.: 726169-73-9
Catalog No.: PC-42903Not For Human Use, Lab Use Only.
Mocetinostat (MGCD-0103) is an isotype-selective small molecule HDAC inhibitor that selectively inhibits HDAC1 (IC50=0.15 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $158 | In stock | |
| 100 mg | $358 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Mocetinostat (MGCD-0103) is an isotype-selective small molecule HDAC inhibitor that selectively inhibits HDAC1 (IC50=0.15 uM).
Mocetinostat (MGCD-0103) also inhibits HDAC2/3/11, but has no effect on HDAC4/5/6/7/8.
Mocetinostat (MGCD-0103) induces hyperacetylation of histones and caused cell cycle blockade in various human cancer cell lines.
Mocetinostat (MGCD-0103) inhibits growth of human tumor xenografts in nude mice.
Mocetinostat (MGCD-0103) is orally bioactive.
| M.Wt | 396.4445 | |
| Formula | C23H20N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzamide, N-(2-aminophenyl)-4-[[[4-(3-pyridinyl)-2-pyrimidinyl]amino]methyl]- |
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1. Fournel M, et al. Mol Cancer Ther. 2008 Apr;7(4):759-68.
2. Zhou N, et al. J Med Chem. 2008 Jul 24;51(14):4072-5.
3. Raeppel S, et al. Bioorg Med Chem Lett. 2009 Feb 1;19(3):644-9.
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