Mocetinostat (MGCD0103) is an isotype-selective small molecule class I HDAC inhibitor with IC50 of 0.15/0.29/1.66 uM for HDAC1/2/3.
Mocetinostat (MGCD0103) also inhibits HDAC11 (IC50=0.59 uM), but has no effect on HDAC4/5/6/7/8.
Mocetinostat (MGCD0103) induces hyperacetylation of histones and caused cell cycle blockade in various human cancer cell lines.
Mocetinostat (MGCD0103) inhibits growth of human tumor xenografts in nude mice.
Mocetinostat (MGCD0103) is orally bioactive.
