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Mocravimod

Chemical Structure : Mocravimod

CAS No.: 509092-16-4

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Mocravimod (KRP-203, KRP203)

Catalog No.: PC-60049Not For Human Use, Lab Use Only.

Mocravimod (KRP203) is a synthetic immunosuppressant that functions as a S1P1 receptor agonist.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Mocravimod (KRP203) is a synthetic immunosuppressant that functions as a S1P1 receptor agonist.
    Mocravimod (KRP203) significantly inhibits infiltration of inflammatory cells, expression of endothelin-1 and TGF-beta1, and IgG deposition and eventually attenuates neointimal formation and myocardial fibrosis.
    Mocravimod (KRP203) prolongs graft survival and attenuates chronic rejection in rat skin and heart allografts.

    Physicochemical Properties

    M.Wt 443.986
    Formula C24H26ClNO3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-Amino-2-(2-(2-chloro-4-(3-benzyloxyphenylthio)phenyl)ethyl)-1,3-propanediol

    References

    1. Shimizu H, et al. Circulation. 2005 Jan 18;111(2):222-9.

    2. Takahashi M, et al. Transplant Proc. 2005 Jan-Feb;37(1):143-5.

    3. Suzuki C, et al. J Heart Lung Transplant. 2006 Mar;25(3):302-9.

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