Catalog No.: PC-43487Not For Human Use, Lab Use Only.
Montelukast sodium (MK0476, MK-0476) is a potent, selective, orally active leukotriene D4 (LTD4) receptor (CysLT1 receptor) antagonist with Ki of 0.18 nM for guinea pig lung LTD4.
Montelukast sodium (MK0476, MK-0476) is a potent, selective, orally active leukotriene D4 (LTD4) receptor (CysLT1 receptor) antagonist with Ki of 0.18 nM for guinea pig lung LTD4.
Montelukast sodium (MK0476) shows no significant affinity for leukotriene C4 and leukotriene B4 receptors.
Montelukast sodium (MK0476) is a potent and competitive antagonist of leukotriene D4-induced contractions of non-tonal guinea-pig trachea with pA2 of 9.3.
Montelukast sodium (MK0476) antagonizes bronchoconstriction induced in anesthetized guinea pigs by i.v. leukotriene D4, blocks leukotriene D4 induced bronchoconstriction in vivo.
Physicochemical Properties
M.Wt
608.17
Formula
C35H35ClNNaO3S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
H2O: ≥ 70 mg/mL
Chemical Name/SMILES
Cyclopropaneacetic acid, 1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]-, sodium salt (1:1)
References
1. Jones TR, et al. Can J Physiol Pharmacol. 1995 Feb;73(2):191-201.
