Catalog No.: PC-49356Not For Human Use, Lab Use Only.
Mortaparib is a dual inhibitor of mortalin-PARP1 interaction, and a p53 activating cytotoxic compound, induces activation of growth arrest and apoptosis signaling in cancer cells in vitro and in vivo.
Mortaparib is a dual inhibitor of mortalin-PARP1 interaction, and a p53 activating cytotoxic compound, induces activation of growth arrest and apoptosis signaling in cancer cells in vitro and in vivo.
Mortaparib is toxic in the range of 2–5 μM in HeLa, ME180, SKG-II and SKG-IIIb (cervical cancer), SKOV-3 and OVK18 (ovarian cancer) cells.
Mortaparib-treated cells showed p53-mediated growth arrest and apoptosis, showed decrease in anti-apoptotic proteins: Bcl-2, COX-1, COX-IV and Procaspase-3, -7 and -9.
Mortaparib caused inhibition of PARP1 and activation of DNA damage stress signaling in HeLa cells.
Mortaparib-treated (20 mg/kg body weight) mice showed suppression of tumor growth in subcutaneous xenografts of SKOV-3 cells; and was not toxic to mice.
