Moxetumomab
(Anti-human CD22 mAb, human IgG1-Kappa)
Catalog No.: PC-Ab1113Not For Human Use, Lab Use Only.
Moxetumomab pasudotox is an anti-CD22 monoclonal antibody fused to a 38 kDa fragment of Pseudomonas exotoxin A, PE38. Moxetumomab binds to CD22 on HCL cells and leads to apoptotic cell death after internalization and trafficking of the toxin to the cytosol. CD22 is a single chain integral membrane molecule and a member of the immunoglobulin gene superfamily, an inhibitory B lymphocyte receptor specifically recognizing α2,6 sialic acids. It functions as an adhesion receptor and a signaling molec
Moxetumomab pasudotox is an anti-CD22 monoclonal antibody fused to a 38 kDa fragment of Pseudomonas exotoxin A, PE38. Moxetumomab binds to CD22 on HCL cells and leads to apoptotic cell death after internalization and trafficking of the toxin to the cytosol. CD22 is a single chain integral membrane molecule and a member of the immunoglobulin gene superfamily, an inhibitory B lymphocyte receptor specifically recognizing α2,6 sialic acids. It functions as an adhesion receptor and a signaling molecule, which appears to be involved in regulating the expression of surface IgM on peripheral B-cells and Ca++ flux in response to immunoglobulin signaling.
Physicochemical Properties
M.Wt
Formula
Human IgG1-Kappa
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
PBS, pH 7.0
Contains no stabilizers or preservatives
