MraY inhibitor 12a

Chemical Structure : MraY inhibitor 12a

Catalog No.: PC-24024Not For Human Use, Lab Use Only.

MraY inhibitor 12a is a first-in-class, non-nucleoside inhibitor of bacterial enzyme MraY with IC50 of 25 uM, exhibits broad-spectrum antibacterial activity.

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Biological Activity

MraY inhibitor 12a is a first-in-class, non-nucleoside inhibitor of bacterial enzyme MraY with IC50 of 25 uM, exhibits broad-spectrum antibacterial activity.
MraY inhibitor 12a demonstrates broad-spectrum antibacterial activity against E. faecium , methicillin-resistant S. aureus (MRSA), vancomycin-resistant Enterococci (VRE) strains and Mycobacterium tuberculosis.

Physicochemical Properties

M.Wt	560.07
Formula	C25H30ClN7O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3-((3,5-dinitrobenzyl)thio)-5-(5-(oct-1-yn-1-yl)pyridin-3-yl)-4H-1,2,4-triazol-4-yl)propan-1-amine hydrochloride

References

1. Berida T, et al. bioRxiv [Preprint]. 2025 Jan 31:2025.01.30.635793.

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