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Mtb GuaB-IN-1

Chemical Structure : Mtb GuaB-IN-1

CAS No.: 3100106-23-5

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Mtb GuaB-IN-1

Catalog No.: PC-28180Not For Human Use, Lab Use Only.

Mtb GuaB-IN-1 (Compound 15) is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB2, IMPDH) with IC50 of 1.7 nM, and MIC of0.26 uM for M.tb H37Ra.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Mtb GuaB-IN-1 (Compound 15) is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB, IMPDH) with IC50 of 1.7 nM, and MIC of0.26 uM for M.tb H37Ra.
Mtb GuaB-IN-1 is extremely selective over the human IMPDH ortholog (IC50 > 50 uM).
Mtb GuaB-IN-1 is not cytotoxic against primary human hepatocytes.
Mtb GuaB-IN-1 has a favorable ADME and safety profile.

Physicochemical Properties

M.Wt 423.86
Formula C21H18ClN5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-9-(1-(5-(3-chloro-1H-pyrazol-1-yl)pyridazin-3-yl)ethoxy)-1,2-dihydro-[1,4]oxazino[4,3-a]quinolin-6(4H)-one

References

1. Zhou Y, et al. Bioorg Med Chem Lett. 2025 Mar 1;117:130026.

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