Chemical Structure : Mtb GuaB2 inhibitor G9
CAS No.:
3096055-62-5
Mtb GuaB2 inhibitor G9
Catalog No.: PC-28179Not For Human Use, Lab Use Only.
Mtb GuaB2 inhibitor G9 is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB2) with IC50 of 0.94 nM, and potent MIC against virulent Mtb H37Rv (IC50=58 nM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Mtb GuaB2 inhibitor G9 is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB2) with IC50 of 0.94 nM, and potent MIC against virulent Mtb H37Rv (IC50=58 nM).
G9 shows high selectivity for bacterial GuaB over the human homology hIMPDH2 (hIMPDH2 IC50 >50 uM).
G9 is efficacious against Mycobacterium tuberculosis as a single agent and in combination with other antibiotics in the chronic C57BL/6, BALB/c, and C3HeB/FeJ mouse models of lung infection.
Physicochemical Properties
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M.Wt
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380.45
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Formula
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C21H24N4O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(1S,3s)-3-(4-((R)-1-((1,4-dihydro-2H-pyrano[3,4-c]quinolin-9-yl)oxy)ethyl)-1H-1,2,3-triazol-1-yl)-1-methylcyclobutan-1-ol
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References
1. Eric M. Kofoed, et al. Development of GuaB Inhibitors to Treat Mycobacterium tuberculosis Infection. ACS Infect. Dis. (2026).
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