Mtb IMPDH2-IN-2

Chemical Structure : Mtb IMPDH2-IN-2

Catalog No.: PC-27279Not For Human Use, Lab Use Only.

MtbIMPDH2-IN-2 is a potent, selective Mycobacterium tuberculosis (Mtb) inosine 5'-monophosphate dehydrogenase 2 (MtbIMPDH2) inhibitor with IC50 of 12 nM, and MIC of 12 uM for Mtb, blocks the biosynthesis of guanine nucleotides.

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Biological Activity

Physicochemical Properties

M.Wt	428.27
Formula	C21H15Cl2N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S)-2-(2,3-Dichlorophenoxy)-N-[2-(4-pyridinyl)-5-benzoxazolyl]propanamide

References

1. Chacko S, et al. J Med Chem. 2018;61(11):4739-4756.

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Mtb IMPDH2-IN-2

Biological Activity

Physicochemical Properties

References

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