MtbIMPDH2 inhibitor P41

Chemical Structure : MtbIMPDH2 inhibitor P41

Catalog No.: PC-28184Not For Human Use, Lab Use Only.

MtbIMPDH2 inhibitor P41 is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB, MtbIMPDH) with Ki app of 17 nM for MtbIMPDH2ΔCBS, displays significant activity against Mtb strain H37Rv in minimal BSA-free medium with MIC of 5 uM.

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Biological Activity

MtbIMPDH2 inhibitor P41 is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB2, MtbIMPDH2) with Ki app of 17 nM for MtbIMPDH2ΔCBS, displays significant activity against Mtb strain H37Rv in minimal BSA-free medium with MIC of 5 uM.

Physicochemical Properties

M.Wt	399.92
Formula	C22H26ClN3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-chloro-N,N-dimethyl-5-(3-(2-(3-(prop-1-en-2-yl)phenyl)propan-2-yl)ureido)benzamide

References

1. Makowska-Grzyska M, et al. PLoS One. 2015 Oct 6;10(10):e0138976.

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