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Chemical Structure : Mufemilast
Catalog No.: PC-73431Not For Human Use, Lab Use Only.
Mufemilast (Hemay005) is a potent, selective, first-in-class PDE4 inhibitor with in vitro IC50 of 80-120 nM, exhibits comparable inhibitory activities to apremilast.
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Mufemilast (Hemay005) is a potent, selective, first-in-class PDE4 inhibitor with in vitro IC50 of 80-120 nM, exhibits comparable inhibitory activities to apremilast.
Hemay005 displayed a significant inhibitory effect on TNF-α, which was an important proinflammatory cytokine target in the disease process of psoriasis.
Hemay005 exhibited a considerable efficacy in psoriasis xenograft SCID mouse model compared with apremilast at the same dose of 20 mg/kg per day in the reduction of psoriasis area and epidermal thickness, protein expression changes and
histological scores.
| M.Wt | 466.523 | |
| Formula | C20H22N2O7S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Xuemei Liu, et al. Bioanalysis. 2018 Jun 1;10(11):863-875.
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