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Chemical Structure : Mutant IDH1-IN-1
Catalog No.: PC-43052Not For Human Use, Lab Use Only.
Mutant IDH1-IN-1 is a potent, mutant-selective IDH1 inhibitor with with IC50s of 4, 42, 80 and 143 nM against mutant IDH1 R132C/R132C, IDH1 R132H/R132H, IDH1 R132H/WT and wild type IDH1, respectively.
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Mutant IDH1-IN-1 is a potent, mutant-selective IDH1 inhibitor with with IC50s of 4, 42, 80 and 143 nM against mutant IDH1 R132C/R132C, IDH1 R132H/R132H, IDH1 R132H/WT and wild type IDH1, respectively; inhibits 2HG production in R132H IDH1-expressing HEK-293 cells with IC50 of 81.5 nM.
| M.Wt | 498.5912 | |
| Formula | C30H31FN4O2 | |
| Appearance | Solid | |
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| Solubility |
DMSO: ≥ 45 mg/mL |
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1. Deng G, et al. J Biol Chem. 2015 Jan 9;290(2):762-74.
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