Mutant KCNJ5 agonist C105

Chemical Structure : Mutant KCNJ5 agonist C105

Catalog No.: PC-27765Not For Human Use, Lab Use Only.

Mutant KCNJ5 agonist C105 is a selective, first-in-class mutant KCNJ5 (GIRK4) agonist, increases mutant KCNJ5-induced cell death in adrenal cells, without affecting cells expressing wild-type KCNJ5.

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Biological Activity

Mutant KCNJ5 agonist C105 is a selective, first-in-class mutant KCNJ5 (GIRK4) agonist, increases mutant KCNJ5-induced cell death in adrenal cells, without affecting cells expressing wild-type KCNJ5.

Physicochemical Properties

M.Wt	466.87
Formula	C24H17ClF2N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2'-amino-6-chloro-1'-[2,4-difluorophenyl]-7-methyl-2,5'-dioxo-1,2,5',6',7',8'-hexahydro-1'H-spiro[indole-3,4'-quinoline]-3'-carbonitrile

References

1. Mir-Bashiri S, et al. Hypertension. 2026 Aug 17. doi: 10.1161/HYPERTENSIONAHA.126.27181.

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