Chemical Structure : MyD88 inhibitor 3g
CAS No.:
MyD88 inhibitor 3g
Catalog No.: PC-25527Not For Human Use, Lab Use Only.
MyD88 inhibitor 3g is a potent, TIR domain-selective and orally bioavailable MyD88 inhibitor, binds TIR domain (SPR KD=28.5 uM) but not the DD domain, disrupts MyD88 dimerization.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MyD88 inhibitor 3g is a potent, TIR domain-selective and orally bioavailable MyD88 inhibitor, binds TIR domain (SPR KD=28.5 uM) but not the DD domain, disrupts MyD88 dimerization.
MyD88 inhibitor 3g significantly suppressed IL-6 secretion from J774A.1 cells (IC50 = 1.32 μM) and THP-1 cells (IC50 = 0.75 μM). MyD88 inhibitor 3g inhibited the activation of the NF-κB and MAPK pathways stimulated by LPS.
MyD88 inhibitor 3g exhibited anti-inflammatory function by binding to the TIR domain instead of the DD domain.
MyD88 inhibitor 3g demonstrated significant anti-inflammatory efficacy and offered substantial protection against LPS and CLP-induced ALI.
Physicochemical Properties
|
M.Wt
|
508.55
|
|
Formula
|
C24H24N6O5S
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
4-(4-(4-Cyanobenzyl)piperazin-1-yl)-N-(6-methoxypyridin-3-yl)-3-nitrobenzenesulfonamide
|
References
1. Pan Chen, et al. J Med Chem. 2025 Sep 12. doi: 10.1021/acs.jmedchem.5c01786.
Contact Us
sales@probechem.com
