Chemical Structure : MyD88 inhibitor 3g
CAS No.:
MyD88 inhibitor 3g
Catalog No.: PC-25527Not For Human Use, Lab Use Only.
MyD88 inhibitor 3g is a potent, TIR domain-selective and orally bioavailable MyD88 inhibitor, binds TIR domain (SPR KD=28.5 uM) but not the DD domain, disrupts MyD88 dimerization.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MyD88 inhibitor 3g is a potent, TIR domain-selective and orally bioavailable MyD88 inhibitor, binds TIR domain (SPR KD=28.5 uM) but not the DD domain, disrupts MyD88 dimerization.
MyD88 inhibitor 3g significantly suppressed IL-6 secretion from J774A.1 cells (IC50 = 1.32 μM) and THP-1 cells (IC50 = 0.75 μM). MyD88 inhibitor 3g inhibited the activation of the NF-κB and MAPK pathways stimulated by LPS.
MyD88 inhibitor 3g exhibited anti-inflammatory function by binding to the TIR domain instead of the DD domain.
MyD88 inhibitor 3g demonstrated significant anti-inflammatory efficacy and offered substantial protection against LPS and CLP-induced ALI.
Physicochemical Properties
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M.Wt
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508.55
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Formula
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C24H24N6O5S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-(4-(4-Cyanobenzyl)piperazin-1-yl)-N-(6-methoxypyridin-3-yl)-3-nitrobenzenesulfonamide
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References
1. Pan Chen, et al. J Med Chem. 2025 Sep 12. doi: 10.1021/acs.jmedchem.5c01786.
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