Chemical Structure : MyD88 inhibitor A5S
CAS No.:
MyD88 inhibitor A5S
Catalog No.: PC-23608Not For Human Use, Lab Use Only.
MyD88 inhibitor A5S is a specific small molecule MyD88 inhibitor with SPR Kd of 15 uM, exerts anti-inflammatory effect through the NF-κB/MAPK pathway.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MyD88 inhibitor A5S is a specific small molecule MyD88 inhibitor with SPR Kd of 15 uM, exerts anti-inflammatory effect through the NF-κB/MAPK pathway.
A5S reduces release of the LPS-induced IL-6 and TNF-α in J774A.1 cells with IC50 of 0.24 uM and 3.28 μM, respectively.
A5S restores IκB-α levels and suppressed the phosphorylation of p65.
A5S interferes with MyD88 homologous dimerization and inhibits MAPK pathway activation.
A5S protects mice from LPS-induced and sepsis-induced acute lung injury (ALI) mouse models.
A5S is a MyD88 inhibitor of not affecting the expression of IFN-β in acquired immunity in suppressing excessive inflammatory response.
Physicochemical Properties
|
M.Wt
|
444.37
|
|
Formula
|
C22H26BrN3O2
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
(S)-1-(4-((1H-Indol-2-yl)methyl)piperazin-1-yl)-3-(4-bromophenoxy)propan-2-ol
|
References
1. Pan Chen, et al. Journal of Medicinal Chemistry. December 7, 2024
Contact Us
sales@probechem.com
