Chemical Structure : MyD88 inhibitor C17
CAS No.:
2911609-80-6
MyD88 inhibitor C17
Catalog No.: PC-21177Not For Human Use, Lab Use Only.
MyD88 inhibitor C17 is a highly potent inhibitor of myeloid differentiation primary response protein 88 (MyD88), dose-dependently inhibits LPS-induced IL-6 and TNF-α in J774A.1 macrophages with IC50 of 2.17 and 8.17 uM, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MyD88 inhibitor C17 is a highly potent inhibitor of myeloid differentiation primary response protein 88 (MyD88), dose-dependently inhibits LPS-induced IL-6 and TNF-α in J774A.1 macrophages with IC50 of 2.17 and 8.17 uM, respectively.
MyD88 inhibitor C17 directly interacts with MyD88 in a dose-dependent manner with Kd of 53 uM in SPR assays.
MyD88 inhibitor C17 also shows inhibition on the release of cytokines in LPS-stimulated human THP-1 cells, suppresses TLR-MyD88 signaling in response to LPS stimulation.
MyD88 inhibitor C17 inhibits the interaction of TLR4 and MyD88 and suppressed the NF-κB pathway.
MyD88 inhibitor C17 treatment (20 mg/kg, orally) led to the accumulation in the lungs of rats and attenuated LPS-induced ALI mice model, with negligible toxicity in vivo.
Physicochemical Properties
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M.Wt
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528.54
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Formula
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C23H24N6O7S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(6-Methoxypyridin-3-yl)-3-nitro-4-(4-(3-nitrobenzyl)piperazin-1-yl)benzenesulfonamide
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References
1. Pan Chen, et al. J Med Chem. 2023 May 25;66(10):6938-6958.
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