MyD88 molecular glue degrader d21

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Chemical Structure : MyD88 molecular glue degrader d21

Catalog No.: PC-27042Not For Human Use, Lab Use Only.

MyD88 molecular glue degrader d21 is a molecular glue degrader of MyD88, inhibits NF-κB pathway activation by facilitating the interaction between E3 ubiquitin ligase RNF126 and MyD88, thereby promoting ubiquitination and subsequent degradation of MyD88, inhibits cytotoxicity of IL-6 in J774A.1 cells with IC50 of 0.42 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	510.53
Formula	C23H22N6O6S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-1-(4-(4-((5-amino-1H-pyrazol-1-yl)sulfonyl)-2-nitrophenyl)piperazin-1-yl)-4-phenylbut-2-ene-1,4-dione

References

1. Zhu L, et al. J Med Chem. 2026 Jun 12. doi: 10.1021/acs.jmedchem.6c00755.

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