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Mycophenolic acid

Chemical Structure : Mycophenolic acid

CAS No.: 24280-93-1

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Mycophenolic acid (Mycophenolate)

Catalog No.: PC-28222Not For Human Use, Lab Use Only.

Mycophenolic acid (MPA, Mycophenolate) is a potent, specific, reversible inosine monophosphate dehydrogenase (IMPDH) inhibitor with EC50 of 0.24 uM, inhibits de-novo purine synthesis required for nucleotide base formation, shows antifungal, antibacterial, and immunosuppressive properties.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Mycophenolic acid (MPA, Mycophenolate) is a potent, specific, reversible inosine monophosphate dehydrogenase (IMPDH) inhibitor with EC50 of 0.24 uM, inhibits de-novo purine synthesis required for nucleotide base formation, shows antifungal, antibacterial, and immunosuppressive properties.

Physicochemical Properties

M.Wt 320.34
Formula C17H20O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid

References

1. Lee HJ, et al. Cancer Res. 1985 Nov;45(11 Pt 1):5512-20.

2. Collart FR, et al. Mol Cell Biol. 1987 Sep;7(9):3328-31.

3. Sophie Domhan, et al. Mol Cancer Ther. 2008 Jun;7(6):1656-68.

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