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N-19004

Chemical Structure : N-19004

CAS No.: 2996841-28-0

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N-19004 (N19004)

Catalog No.: PC-25276Not For Human Use, Lab Use Only.

N-19004 is a potent, specific formyl peptide receptor (FPR1) antagonist with IC50 of 68.9 nM for inhibition of the binding of FITC-fMLF to THP-1 cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

N-19004 is a potent, specific formyl peptide receptor (FPR1) antagonist with IC50 of 68.9 nM for inhibition of the binding of FITC-fMLF to THP-1 cells.
N-19004 hampers THP-1 cell migration triggered by the CCL2 chemokine in a dose-dependent manner (IC50=10 nM).
N-19004 (20 mg/kg) effectively reduced the lesion extravasation area, improved edema resorption by a systemic administration route in mouse model of choroidal neovascularization (CNV).

Physicochemical Properties

M.Wt 562.74
Formula C29H38N8O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N,N'-(5-(tert-butyl)-2-((naphthalen-2-ylmethyl)thio)-1,3-phenylene)bis(3-((diaminomethylene)amino)propanamide)

References

1. De Fenza M, et al. ACS Pharmacol Transl Sci. 2024 Oct 23;7(11):3476-3487.

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