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N-Desethyl Sunitinib

Chemical Structure : N-Desethyl Sunitinib

CAS No.: 356068-97-8

N-Desethyl Sunitinib (SU11662, SU-11662)

Catalog No.: PC-42725Not For Human Use, Lab Use Only.

N-Desethyl Sunitinib is the active metabolite of sunitinib, which is an oral, small-molecule, multi-targeted RTKs inhibitor, sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

N-Desethyl Sunitinib is the active metabolite of sunitinib, which is an oral, small-molecule, multi-targeted RTKs inhibitor, sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor.

Physicochemical Properties

M.Wt 370.4206
Formula C20H23FN4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1H-Pyrrole-3-carboxamide, N-[2-(ethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-

References

1. Chen X, et al. Biomed Chromatogr. 2015 May;29(5):679-88.

2. Lankheet NA, et al. Br J Cancer. 2014 May 13;110(10):2441-9.

3. Tang SC, et al. J Pharmacol Exp Ther. 2012 Apr;341(1):164-73.

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