Catalog No.: PC-23090Not For Human Use, Lab Use Only.
N-WASP inhibitor 187-1 is a 14-aa cyclic peptide that potently inhibits actin assembly induced by PIP2 (IC50=2 uM), binds and inhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by an allosteric mechanism, inhibits N-WASP activation of the Arp2/3 complex.
N-WASP inhibitor 187-1 is a 14-aa cyclic peptide that potently inhibits actin assembly induced by PIP2 (IC50=2 uM), binds and inhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by an allosteric mechanism, inhibits N-WASP activation of the Arp2/3 complex.
Physicochemical Properties
M.Wt
1784.11
Formula
C96H122N18O16
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
cyclo(lLys-dPhe-dPro-dPhe-lPhe-dPro-lGln)2
References
1. Peterson JR, et al. Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10624-9.
