Catalog No.: PC-61325Not For Human Use, Lab Use Only.
N-butylidenephthalide (NSC 325307) is a natural compound derived from Angelica sinensis that inhibits malignant brain tumor growth in vitro and in vivo.
N-butylidenephthalide (NSC 325307) is a natural compound derived from Angelica sinensis that inhibits malignant brain tumor growth in vitro and in vivo.
N-butylidenephthalide upregulates the expression of p21 and p27, decrease sphosphorylation of Rb proteins, causes cell arrest at the G0/G1 phase in GBM tumor cells.
N-butylidenephthalide inhibits the expression of Axl and reduces the migratory and invasive capabilities of GBM cells.
N-butylidenephthalide inhibits tumour growth and suppresses Axl expression in tumour models.
Physicochemical Properties
M.Wt
188.226
Formula
C12H12O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Phthalide, 3-butylidene- (6CI,7CI,8CI)
References
1. Yen SY, et al. Oncogene. 2016 Apr 28;35(17):2156-65.
2. Lin PC, et al. J Neurochem. 2008 Aug;106(3):1017-26.
3. Tsai NM, et al. J Neurochem. 2006 Nov;99(4):1251-62.
