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N.41

Chemical Structure : N.41

CAS No.: 357441-99-7

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N.41 (HIV inhibitor N.41; Vif inhibitor N.41)

Catalog No.: PC-60887Not For Human Use, Lab Use Only.

N.41 (HIV inhibitor N.41, Vif inhibitor N.41) is a novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G (A3G) protein (IC50=2.2 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    N.41 (HIV inhibitor N.41, Vif inhibitor N.41) is a novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G (A3G) protein (IC50=2.2 uM).
    N.41 shows potent antiviral activity in A3G(+) but not in A3G(-) T cells with IC50 of 8.4 uM and TC50 of >100 uM against HIV-1Ba-L replication in peripheral blood mononuclear cells.
    N.41 inhibits the Vif-A3G interaction and increases cellular A3G levels and incorporation of A3G into virions, thereby attenuating virus infectivity in a Vif-dependent manner.

    Physicochemical Properties

    M.Wt 254.289
    Formula C15H14N2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-((4-hydroxyphenyl)amino)-1-(pyridin-3-yl)but-2-en-1-one

    References

    1. Pery E, et al. J Biol Chem. 2015 Apr 17;290(16):10504-17.

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