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Chemical Structure : N.41
Catalog No.: PC-60887Not For Human Use, Lab Use Only.
N.41 (HIV inhibitor N.41, Vif inhibitor N.41) is a novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G (A3G) protein (IC50=2.2 uM).
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N.41 (HIV inhibitor N.41, Vif inhibitor N.41) is a novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G (A3G) protein (IC50=2.2 uM).
N.41 shows potent antiviral activity in A3G(+) but not in A3G(-) T cells with IC50 of 8.4 uM and TC50 of >100 uM against HIV-1Ba-L replication in peripheral blood mononuclear cells.
N.41 inhibits the Vif-A3G interaction and increases cellular A3G levels and incorporation of A3G into virions, thereby attenuating virus infectivity in a Vif-dependent manner.
| M.Wt | 254.289 | |
| Formula | C15H14N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Pery E, et al. J Biol Chem. 2015 Apr 17;290(16):10504-17.
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