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Chemical Structure : N6022
CAS No.: 1208315-24-5
Catalog No.: PC-44142Not For Human Use, Lab Use Only.
A potent and reversible S-Nitrosoglutathione reductase (GSNOR) inhibitor with IC50 of 20 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $112 | In stock | |
| 50 mg | $336 | In stock | |
| 100 mg | $552 | In stock |
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A potent and reversible S-Nitrosoglutathione reductase (GSNOR) inhibitor with IC50 of 20 nM; reduces bronchoconstriction and pulmonary inflammation in a mouse model of asthma and demonstrates an acceptable safety profile.
Asthma
Phase 2 Clinical
| M.Wt | 414.4565 | |
| Formula | C24H22N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 46 mg/mL |
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| Chemical Name/SMILES |
1H-Pyrrole-2-propanoic acid, 1-[4-(aminocarbonyl)-2-methylphenyl]-5-[4-(1H-imidazol-1-yl)phenyl]- |
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1. Sun X, et al. ACS Med Chem Lett. 2011 Mar 11;2(5):402-6.
2. Sun X, et al. ACS Med Chem Lett. 2011 Mar 11;2(5):402-6.
3. Green LS, et al. Biochemistry. 2012 Mar 13;51(10):2157-68.
4. Blonder JP, et al. BMC Pulm Med. 2014 Jan 10;14:3.
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