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You are here:Home-Chemical Inhibitors & Agonists-Metabolic Enzyme/Protease-S-nitrosoglutathione reductase (GSNOR)-N6022
N6022

Chemical Structure : N6022

CAS No.: 1208315-24-5

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N6022 (N 6022;N-6022)

Catalog No.: PC-44142Not For Human Use, Lab Use Only.

A potent and reversible S-Nitrosoglutathione reductase (GSNOR) inhibitor with IC50 of 20 nM.

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10 mg $112 In stock
50 mg $336 In stock
100 mg $552 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A potent and reversible S-Nitrosoglutathione reductase (GSNOR) inhibitor with IC50 of 20 nM; reduces bronchoconstriction and pulmonary inflammation in a mouse model of asthma and demonstrates an acceptable safety profile.

Asthma

Phase 2 Clinical

Physicochemical Properties

M.Wt 414.4565
Formula C24H22N4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 46 mg/mL
Chemical Name/SMILES

1H-Pyrrole-2-propanoic acid, 1-[4-(aminocarbonyl)-2-methylphenyl]-5-[4-(1H-imidazol-1-yl)phenyl]-

References

1. Sun X, et al. ACS Med Chem Lett. 2011 Mar 11;2(5):402-6.

2. Sun X, et al. ACS Med Chem Lett. 2011 Mar 11;2(5):402-6.

3. Green LS, et al. Biochemistry. 2012 Mar 13;51(10):2157-68.

4. Blonder JP, et al. BMC Pulm Med. 2014 Jan 10;14:3.

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