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NAB-14

Chemical Structure : NAB-14

CAS No.: 1237541-73-9

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NAB-14 (NAB14)

Catalog No.: PC-63207Not For Human Use, Lab Use Only.

NAB-14 is a potent, selective negative allosteric modulator of GluN2C/2D-containing NMDA receptors with IC50 of 580 nM, >800-fold selective over GluN2A/GluN2 receptors.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NAB-14 is a potent, selective negative allosteric modulator of GluN2C/2D-containing NMDA receptors with IC50 of 580 nM, >800-fold selective over GluN2A/GluN2 receptors.
    NAB-14 inhibits triheteromeric (GluN1/GluN2A/GluN2C) NMDARs with modestly reduced potency and efficacy compared to diheteromeric (GluN1/GluN2C/GluN2C) receptors.
    NAB-14 inhibits GluN2D-mediated synaptic currents in rat subthalamic neurons and mouse hippocampal interneurons, but has no effect on synaptic transmission in hippocampal pyramidal neurons.

    Physicochemical Properties

    M.Wt 351.406
    Formula C20H21N3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-((1H-indol-7-yl)carbamoyl)phenyl diethylcarbamate

    References

    1. Swanger SA, et al. ACS Chem Neurosci. 2018 Feb 21;9(2):306-319.

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