Chemical Structure : NAMPT activator compound b2b
CAS No.:
2759101-97-6
NAMPT activator compound b2b
Catalog No.: PC-27316Not For Human Use, Lab Use Only.
NAMPT activator compound b2b is a potent lipid-lowering compound (EC50=0.37 uM) and NAMPT activator, binds to NAMPT with a dissociation constant (KD) of 0.78 uM, inhibits triglyceride biosynthesis by inhibiting ACSL1 in adipocytes.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
NAMPT activator compound b2b is a potent lipid-lowering compound (EC50=0.37 uM) and NAMPT activator, binds to NAMPT with a dissociation constant (KD) of 0.78 uM, inhibits triglyceride biosynthesis by inhibiting ACSL1 in adipocytes.
b2b suppressed lipid accumulation throughout all stages of adipocyte differentiation.
b2b attenuates diet-induced obesity and improves metabolic health in mice.
b2b disrupts LCFA flux and triglyceride biosynthesis by inhibiting the expression of ACSL1 in 3T3-L1 adipocytes.
b2b inhibits TG biosynthesis by regulating ACSL1 expression through NAMPT-NAD+-SIRT1 axis.
Physicochemical Properties
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M.Wt
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372.45
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Formula
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C21H16N4OS
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(1H-indol-2-yl)-7-((thiophen-2-ylmethyl)amino)quinazolin-4(3H)-one
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References
1. Zhi Jiang, et al. Acta Pharm Sin B. 2026 Jul;16(7):4478-4490.
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