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NBD-11021

Chemical Structure : NBD-11021

CAS No.: 1427304-84-4

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NBD-11021 (NBD11021)

Catalog No.: PC-70010Not For Human Use, Lab Use Only.

NBD-11021 (NBD11021) is a small molecule, full antagonist of CD4 that blocks gp120-CD4 interaction.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NBD-11021 (NBD11021) is a small molecule, full antagonist of CD4 that blocks gp120-CD4 interaction.
    NBD-11021 inhibits the CD4-dependent virus in a dose-dependent manner with IC50 of 2.4 uM.
    NBD-11021 also weakly shows HIV-1 RT inhibition with IC50 of 43.4 uM.
    NBD-11021 exhibits pan-neutralization activity against a panel of 56 Env-pseudotyped HIV-1 representing diverse subtypes of clinical isolates (IC50 as low as 270 nM).

    Physicochemical Properties

    M.Wt 444.978
    Formula C22H25ClN4O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-(4-chlorophenyl)-N-((5-(hydroxymethyl)-4-methylthiazol-2-yl)(piperidin-2-yl)methyl)-1H-pyrrole-2-carboxamide

    References

    1. Curreli F, et al. J Med Chem. 2015 Sep 10;58(17):6909-6927.

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