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NBD-14273

Chemical Structure : NBD-14273

CAS No.: 3032325-35-9

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NBD-14273 (NBD 14273)

Catalog No.: PC-73246Not For Human Use, Lab Use Only.

NBD-14273 is a CD4-mimetic, small-molecule HIV-1 entry inhibitor with IC50 of 0.13 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NBD-14273 is a CD4-mimetic, small-molecule HIV-1 entry inhibitor with IC50 of 0.13 uM.
    NBD-14273 showed both improved antiviral activity and selectivity index (SI) against HIV-1HXB2 compared to NBD-14136.
    NBD-14273 displayed potenct against a large panel of 50 HIV-1 Env-pseudotyped viruses representing clinical isolates of diverse subtypes.

    Physicochemical Properties

    M.Wt 442.433
    Formula C19H18F4N4O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1H-Pyrrole-2-carboxamide, N-[(1S)-2-amino-1-[4-(2-hydroxyethyl)-2-thiazolyl]ethyl]-5-[2-fluoro-4-(trifluoromethyl)phenyl]-

    References

    1. Francesca Curreli, et al. Bioorg Med Chem. 2021 Feb 15;32:116000.

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