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NBD-557

Chemical Structure : NBD-557

CAS No.: 333352-59-3

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NBD-557 (NBD 557;NBD557)

Catalog No.: PC-45974Not For Human Use, Lab Use Only.

A potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction.

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10 mg $384 In stock
50 mg $855 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction; inhibits the fusion between HIV-1NL4-3-luc pseudotyped virus expressing HIV-1HXB2 (X4-tropic) envelope and U87-T4-CXCR4 cells with IC50 of 9.7 uM; inhibits the laboratory-adapted HIV-1 strains IIIB, MN, and V32 with IC50 of 5-16 uM.

HIV Infection

Preclinical

Physicochemical Properties

M.Wt 382.2953
Formula C17H24BrN3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Ethanediamide, N-(4-bromophenyl)-N'-(2,2,6,6-tetramethyl-4-piperidinyl)- (9CI)

References

1. Zhao Q, et al. Virology. 2005 Sep 1;339(2):213-25.

2. Schön A, et al. Biochemistry. 2006 Sep 12;45(36):10973-80.

3. Curreli F, et al. Antimicrob Agents Chemother. 2014 Sep;58(9):5478-91.

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