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NBI-27914

Chemical Structure : NBI-27914

CAS No.: 184241-44-9

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NBI-27914 (NBI 27914 )

Catalog No.: PC-21398Not For Human Use, Lab Use Only.

NBI-27914 is a potent, selective antagonist of corticotropin-releasing factor 1 (CRF1) receptor with Ki of 1.7 nM, shows no activity at CRF2 receptors.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NBI-27914 is a potent, selective antagonist of corticotropin-releasing factor 1 (CRF1) receptor with Ki of 1.7 nM, shows no activity at CRF2 receptors.

Physicochemical Properties

M.Wt 434.19
Formula C18H20Cl4N4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-Chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-N'-(2,4,6-trichlorophenyl)-4,6-pyrimidinediamine

References

1. T Z Baram, et al. Brain Res. 1997 Oct 3;770(1-2):89-95.

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