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Chemical Structure : NBI-35965
Catalog No.: PC-21399Not For Human Use, Lab Use Only.
NBI-35965 is a potent, selective antagonist of corticotropin-releasing factor 1 (CRF1) receptor with Ki of 4 nM, >1000-fold selective over CRF2.
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NBI-35965 is a potent, selective antagonist of corticotropin-releasing factor 1 (CRF1) receptor with Ki of 4 nM, >1000-fold selective over CRF2.
NBI-35965 inhibits cAMP accumulation and adrenocorticotropic hormone (ACTH) production in vitro with pIC50 values of 7.1 and 6.9 respectively.
NBI-35965 attenuates CRF and ACTH production in vivo.
NBI-35965 is orally active and brain penetrant with anxiolytic activity.
| M.Wt | 401.34 | |
| Formula | C21H22Cl2N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mulugeta Million, et al. Brain Res. 2003 Sep 19;985(1):32-42.
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