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NBQX

Chemical Structure : NBQX

CAS No.: 118876-58-7

NBQX (FG9202, FG-9202)

Catalog No.: PC-61719Not For Human Use, Lab Use Only.

NBQX is a potent, selective and competitive AMPA receptor (AMPAR) antagonist with IC50 of 0.15 uM.

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Biological Activity

NBQX is a potent, selective and competitive AMPA receptor (AMPAR) antagonist with IC50 of 0.15 uM.
NBQX binds to the quisqualate subtype of the glutamate receptor, with no activity at the NMDA and glycine sites.
NBQX also blocks kainate receptor with IC50 of 4.8 uM.
NBQX exhibits anticonvulsant activity in rodent seizure models.

Physicochemical Properties

M.Wt 336.28
Formula C12H8N4O6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide

References

1. Sheardown MJ, et al. Science. 1990 Feb 2;247(4942):571-4.

2. Klockgether T, et al. Ann Neurol. 1991 Nov;30(5):717-23.

3. Gill R, et al. Brain Res. 1992 May 15;580(1-2):35-43.

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