Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.

You are here:Home-Chemical Inhibitors & Agonists-Ras-Raf-MAPK-ERK Pathway-p38 MAPK-NC-p38i NC-38
NC-p38i NC-38

Chemical Structure : NC-p38i NC-38

CAS No.: 2094511-69-8

NC-p38i NC-38 (Non-canonical p38α inhibitor NC-38)

Catalog No.: PC-20953Not For Human Use, Lab Use Only.

Non-canonical p38α inhibitor NC-38 (NC-p38i NC-38) is a potent, highly selective, non-canonical inhibitor of p38α, inhibits TAB1-induced p38α autophosphorylation in vitro with IC50 of 0.27 uM.

Packing Price Stock Quantity
50 mg Get quote
100 mg Get quote
200 mg Get quote

Bulk size, bulk discount!

Welcome credit card payment!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Non-canonical p38α inhibitor NC-38 (NC-p38i NC-38) is a potent, highly selective, non-canonical inhibitor of p38α, inhibits TAB1-induced p38α autophosphorylation in vitro with IC50 of 0.27 uM.
    NC-38 (1-30 uM) significantly decreases TAB1-induced p38α phosphorylation levels in a dose-dependent manner in HEK293T cells.
    NC-38 does not affect the canonical activation of p38α by the MAP2K MKK6, showed limited activity agianst the kinase activity of p38α on the substrates MK2 and ATF2 at 10 uM.
    NC-38 binds to and stabilizes p38α without inhibiting its interaction with TAB1.
    NC-38 effectively inhibits p38α autophosphorylation by weakly binding to several regions in and around the ATP-binding pocket of p38α.

    Physicochemical Properties

    M.Wt 345.39
    Formula C17H16FN3O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-(2-cyclobutyl-1H-benzo[d]imidazol-6-yl)-2-fluorobenzenesulfonamide

    References

    1. Lorena González, et al. Nat Commun. 2023 Jun 12;14(1):3318.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: