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NCATS-SM5637

Chemical Structure : NCATS-SM5637

CAS No.: 2170615-16-2

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NCATS-SM5637 (NSC 791985)

Catalog No.: PC-72650Not For Human Use, Lab Use Only.

NCATS-SM5637 (NSC 791985) is a potent, selective mutant IDH1 inhibitor with IC50 of 81/72 nM for IDH1 mutant R132H/R132C, respctively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NCATS-SM5637 (NSC 791985) is a potent, selective mutant IDH1 inhibitor with IC50 of 81/72 nM for IDH1 mutant R132H/R132C, respctively.
    NCATS-SM5637 showed higher tumoral concentrations that corresponded to lower 2-HG concentrations in engineered mIDH1-U87-xenograft mouse model, compared with the approved drug AG-120 (ivosidenib).

    Physicochemical Properties

    M.Wt 593.567
    Formula C31H30Cl2N4O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(5-chloro-2-ethylphenyl)-3-(4-(4-chlorophenyl)thiazol-2-yl)-6-(2-methylprop-1-en-1-yl)-5-(piperazine-1-carbonyl)pyridin-2(1H)-one

    References

    1. Rohde JM, et al. J Med Chem. 2021 Apr 22;64(8):4913-4946.

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