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NCGC00071837

Chemical Structure : NCGC00071837

CAS No.: 578747-98-5

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NCGC00071837 (PDE4-IN-5A)

Catalog No.: PC-62068Not For Human Use, Lab Use Only.

NCGC00071837 (PDE4-IN-5A) is a potent, selective PDE4 inhibitor with IC50 of 24 and 18 nM for PDE4A and PDE4D, respectively, weak inhibition for PDE4B (IC50=0.54 uM) and inactive for PDE1/3/5/7/9/10/11.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NCGC00071837 (PDE4-IN-5A) is a potent, selective PDE4 inhibitor with IC50 of 24 and 18 nM for PDE4A and PDE4D, respectively, weak inhibition for PDE4B (IC50=0.54 uM) and inactive for PDE1/3/5/7/9/10/11.
    NCGC00071837 directly stimulates (in the absence of NKH 477) and potentiates (in the presence of NKH 477) cAMP production.

    Physicochemical Properties

    M.Wt 382.438
    Formula C19H18N4O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-(3,4-dimethoxyphenyl)-3-(2-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine

    References

    1. Xia M, et al. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2412-7.

    2. Skoumbourdis AP, et al. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1297-303.

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