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Chemical Structure : NCGC00071837
Catalog No.: PC-62068Not For Human Use, Lab Use Only.
NCGC00071837 (PDE4-IN-5A) is a potent, selective PDE4 inhibitor with IC50 of 24 and 18 nM for PDE4A and PDE4D, respectively, weak inhibition for PDE4B (IC50=0.54 uM) and inactive for PDE1/3/5/7/9/10/11.
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NCGC00071837 (PDE4-IN-5A) is a potent, selective PDE4 inhibitor with IC50 of 24 and 18 nM for PDE4A and PDE4D, respectively, weak inhibition for PDE4B (IC50=0.54 uM) and inactive for PDE1/3/5/7/9/10/11.
NCGC00071837 directly stimulates (in the absence of NKH 477) and potentiates (in the presence of NKH 477) cAMP production.
| M.Wt | 382.438 | |
| Formula | C19H18N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Xia M, et al. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2412-7.
2. Skoumbourdis AP, et al. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1297-303.
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