Catalog No.: PC-60808Not For Human Use, Lab Use Only.
NCGC00379308 (D3-βArr) is a potent, functionally selective TSH receptor (TSHR) positive allosteric modulator with EC50 of 11.6 uM (β-Arr 1 translocation).
NCGC00379308 (D3-βArr) is a potent, functionally selective TSH receptor (TSHR) positive allosteric modulator with EC50 of 11.6 uM (β-Arr 1 translocation).
NCGC00379308 (D3-βArr) does not activate β-Arr 1 translocation to the GLP1R, binds and activates the TSHR and has no agonistic effect on cAMP production nor inhibit TSH-induced cAMP production in DiscoverX1 cells and primary cultures of human thyrocytes.
NCGC00379308 (D3-βArr) potentiates TSH-induced upregulation of ALPL and OPN mRNA levels, and increases TSH-induced secretion of OPN protein.
NCGC00379308 (D3-βArr) potentiates the effect of TSH to enhance differentiation of a human preosteoblast in an in vitro model.
