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Chemical Structure : NCGC00379308
Catalog No.: PC-60808Not For Human Use, Lab Use Only.
NCGC00379308 (D3-βArr) is a potent, functionally selective TSH receptor (TSHR) positive allosteric modulator with EC50 of 11.6 uM (β-Arr 1 translocation).
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NCGC00379308 (D3-βArr) is a potent, functionally selective TSH receptor (TSHR) positive allosteric modulator with EC50 of 11.6 uM (β-Arr 1 translocation).
NCGC00379308 (D3-βArr) does not activate β-Arr 1 translocation to the GLP1R, binds and activates the TSHR and has no agonistic effect on cAMP production nor inhibit TSH-induced cAMP production in DiscoverX1 cells and primary cultures of human thyrocytes.
NCGC00379308 (D3-βArr) potentiates TSH-induced upregulation of ALPL and OPN mRNA levels, and increases TSH-induced secretion of OPN protein.
NCGC00379308 (D3-βArr) potentiates the effect of TSH to enhance differentiation of a human preosteoblast in an in vitro model.
| M.Wt | 333.439 | |
| Formula | C20H23N5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Neumann S, et al. J Pharmacol Exp Ther. 2018 Jan;364(1):38-45.
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