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Chemical Structure : NCH-51
CAS No.: 848354-66-5
Catalog No.: PC-43291Not For Human Use, Lab Use Only.
NCH-51 is the S-isobutyryl prodrug of NCH-31, which is a potent HDAC inhibitor with IC50 of 48 nM for HDAC1, inhibits cell proliferation of NCI-H460 and MDA-MB-231 with IC50 of 2.1 and 4.4 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 25 mg | $198 | In stock | |
| 100 mg | $488 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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NCH-51 is the S-isobutyryl prodrug of NCH-31, which is a potent HDAC inhibitor with IC50 of 48 nM for HDAC1, inhibits cell proliferation of NCI-H460 and MDA-MB-231 with IC50 of 2.1 and 4.4 uM。
NCH-51 inhibits the cell growth of a variety of lymphoid malignant cells through apoptosis induction, more effectively than SAHA, upregulates p21 and downregulated anti-apoptotic molecules including survivin, bcl-w and c-FLIP.
NCH-51 also induces expression of latent HIV-1 through the Sp1 sites with minimal cytotoxicit in latently infected-cells.
| M.Wt | 390.5627 | |
| Formula | C20H26N2O2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Propanethioic acid, 2-methyl-, S-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl] ester |
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1. Sanda T, et al. Leukemia. 2007 Nov;21(11):2344-53.
2. Suzuki T, et al. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1558-61.
3. Suzuki T, et al. J Med Chem. 2005 Feb 24;48(4):1019-32.
4. Victoriano AF, et al. FEBS Lett. 2011 Apr 6;585(7):1103-11.
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