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NCX-4016

Chemical Structure : NCX-4016

CAS No.: 175033-36-0

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NCX-4016 (Nitroaspirin;NO-Aspirin, NCX4016)

Catalog No.: PC-62969Not For Human Use, Lab Use Only.

NCX-4016 (Nitroaspirin, NO-Aspirin 1) is a nitroderivative of aspirin that combines cyclooxygenase inhibitor with an NO donor, directly and irreversiblely inhibits COX-1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NCX-4016 (Nitroaspirin, NO-Aspirin 1) is a nitroderivative of aspirin that combines cyclooxygenase inhibitor with an NO donor, directly and irreversiblely inhibits COX-1.
    NCX-4016 suppresses platelet activation, platelet aggregation and thromboxane A2 production.
    NCX-4016 reduces infarct size caused by myocardial ischemia-reperfusion in the anesthetized rat.

    Physicochemical Properties

    M.Wt 331.28
    Formula C16H13NO7
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(Acetyloxy)-benzoic acid 3-[(nitrooxy)methyl]phenyl ester

    References

    1. Corazzi T, et al. J Pharmacol Exp Ther. 2005 Dec;315(3):1331-7.

    2. Rossoni G, et al. J Pharmacol Exp Ther. 2001 Apr;297(1):380-7.

    3. Lechi C, et al. Thromb Haemost. 1996 Nov;76(5):791-8.

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