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Chemical Structure : ND-2110
Catalog No.: PC-49046Not For Human Use, Lab Use Only.
ND2110 is a highly selective and bioavailable small molecule IRAK4 inhibitor with IC50 of 7.5 nM, no significant activity against IRAK1 (IC50>2000 nM).
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ND2110 is a highly selective and bioavailable small molecule IRAK4 inhibitor with IC50 of 7.5 nM, no significant activity against IRAK1 (IC50>2000 nM).
ND2110 blocks TNF production, collagen-induced arthritis, and gout formation in mice.
ND2110 reduces in vitro viability of multiple ABC DLBCL lines, targets the subset of ABC DLBCL lines with MYD88 L265P mutations, but not ABC DLBCL lines with other MYD88 mutations (S222R and S219C) or those with WT MYD88.
| M.Wt | 416.54 | |
| Formula | C21H28N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Priscilla N Kelly, et al. J Exp Med. 2015 Dec 14;212(13):2189-201.
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