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ND-2110

Chemical Structure : ND-2110

CAS No.: 1388894-17-4

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ND-2110 (ND2110)

Catalog No.: PC-49046Not For Human Use, Lab Use Only.

ND2110 is a highly selective and bioavailable small molecule IRAK4 inhibitor with IC50 of 7.5 nM, no significant activity against IRAK1 (IC50>2000 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ND2110 is a highly selective and bioavailable small molecule IRAK4 inhibitor with IC50 of 7.5 nM, no significant activity against IRAK1 (IC50>2000 nM).
    ND2110 blocks TNF production, collagen-induced arthritis, and gout formation in mice.
    ND2110 reduces in vitro viability of multiple ABC DLBCL lines, targets the subset of ABC DLBCL lines with MYD88 L265P mutations, but not ABC DLBCL lines with other MYD88 mutations (S222R and S219C) or those with WT MYD88.

    Physicochemical Properties

    M.Wt 416.54
    Formula C21H28N4O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (5R)-6,7-Dihydro-4-[[trans-4-(4-morpholinyl)cyclohexyl]oxy]-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidine-5-acetamide

    References

    1. Priscilla N Kelly, et al. J Exp Med. 2015 Dec 14;212(13):2189-201.

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